منابع مشابه
Advances in oral transmucosal drug delivery.
The successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity. Oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. This review highlights the physiological challenges as well as the advances and opportunities fo...
متن کاملOral Transmucosal Delivery for Improved Drug Bioavailability and Patient Compliance
Since last 15 years the number of 505(b)(2) filings with new dosage forms for existing drug molecules at United states Food and Drug Administration (USFDA) has been increased tremendously. This is because of the tremendous increase in the developmental cost of new chemical entities (NCE) and increased concerns about patient preferences and market demands for the novel unconventional dosage form...
متن کاملCellular evaluation of insulin transmucosal delivery.
P(MAA-g-EG) microparticles have been extensively investigated as carriers for oral delivery of proteins such as insulin. In this study, we investigated the effect of the molecular weight of the PEG tethered chains in the copolymer network and of the microparticle size on the transepithelial electrical resistance (TEER) and insulin epithelial permeability, using monolayers of human intestinal ep...
متن کاملDevelopment of a Lozenge for Oral Transmucosal Delivery of Trans-Resveratrol in Humans: Proof of Concept
Resveratrol provides multiple physiologic benefits which promote healthspan in various model species and clinical trials support continued exploration of resveratrol treatment in humans. However, there remains concern regarding low bioavailability and wide inter-individual differences in absorption and metabolism in humans, which suggests a great need to develop novel methods for resveratrol de...
متن کاملNoninvasive Transdermal and Transmucosal Drug Delivery Technologies
Overcoming the barrier function of the skin already poses a great challenge to modern drug delivery systems, but no less important are safety and tolerability aspects. In the past, many common drug penetration enhancement strategies turned out to destroy the natural barrier function of the skin and cause irritations and other partially severe side-effects. Therefore, right from the beginning MI...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2016
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2016.06.039